Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation
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چکیده
منابع مشابه
Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation.
Mutations in TRPM1 are found in humans with an autosomal recessive form of complete congenital stationary night blindness (cCSNB). The Trpm1(-/-) mouse has been an important animal model for this condition. Here we report a new mouse mutant, tvrm27, identified in a chemical mutagenesis screen. Genetic mapping of the no b-wave electroretinogram (ERG) phenotype of tvrm27 localized the mutation to...
متن کاملDepolarizing Bipolar Cell Dysfunction due to a Trpm 1 Point Mutation 1
Mutations in TRPM1 are found in humans with an autosomal recessive form of 25 complete congenital stationary night blindness (cCSNB). The Trpm1 mouse has been an 26 important animal model for this condition. Here we report a new mouse mutant, tvrm27, 27 identified in a chemical mutagenesis screen. Genetic mapping of the no b-wave 28 electroretinogram (ERG) phenotype of tvrm27 localized the muta...
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The ON pathway of the visual system, which detects increases in light intensity, is established at the first retinal synapse between photoreceptors and ON-bipolar cells. Photoreceptors hyperpolarize in response to light and reduce the rate of glutamate release, which in turn causes the depolarization of ON-bipolar cells. This ON-bipolar cell response is mediated by the metabotropic glutamate re...
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BACKGROUND Paraneoplastic retinopathy (PR), including cancer-associated retinopathy (CAR) and melanoma-associated retinopathy (MAR), is a progressive retinal disease caused by antibodies generated against neoplasms not associated with the eye. While several autoantibodies against retinal antigens have been identified, there has been no known autoantibody reacting specifically against bipolar ce...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2012
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00137.2012